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Human Skin Model with Neural & Immune Mechanisms Developed

Breaking research: Human Skin Model with Neural & Immune Mechanisms Developed

Researchers at Tufts University developed a new, more complex human skin model, using primary human cells which have neural and immune components replicating key function of skin biology.
Researchers now have a highly relevant, complete in vitro model for clinical and exploratory research involving human skin within their reach.

The construction of this new system is essential to understanding the functions of human skin, including stimuli, sensation, immune and neural responses. The human skin equivalent contains important cell types, such as adipose, neural, and immune components, which add an additional layer of complexity to this model, compared to previous human skin equivalents. The additional intricacy will provide a deeper insight into poorly understood diseases, like psoriasis.

This model is the first to include genes associated with skin development, hallmark adipogenesis, immune system process, inflammatory response, and nervous system development.

Vidal Yucha SE, Tamamoto KA, Nguyen H, et al. Human skin equivalents demonstrate need for neuro-immuno-cutaneous system. Advanced Biosystems. 2018. doi: 10.1002/adbi.201800283

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