Adopting human-focused research framework may help produce results more relevant to human physiology and overcome translational barriers in diabetes research.
Using animal models for researching type 2 diabetes mellitus (T2DM) impedes scientific breakthroughs about the disease origins and treatment options.
Researchers recently proposed a human-centered research framework to study the biology of sugar metabolism in humans from molecules to population studies by utilizing novel human-based research technologies such as organ-on-chips and computer simulations.
This human-relevant framework, which incorporates in human cells and tissues and computer modeling technologies, holds great promise to advance the current prevention, diagnosis, and treatment of T2DM in humans.
Ali Z, Chandrasekera PC, Pippin JP. Animal research for type 2 diabetes mellitus: limited translation to clinical benefit and the path forward. Altern Lab Anim. Mar 2018. Retrieved from http://www.atla.org.uk/animal-research-for-type-2-diabetes-mellitus-its-…